A novel in situ monitoring system of 3D engineered muscle

TitleA novel in situ monitoring system of 3D engineered muscle
Publication TypeConference Paper
Year of Publication2020
AuthorsX Zhang, and GA Truskey
Conference Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Date Published01/2020
Abstract

In this work, we developed an in situ force monitoring system of skeletal muscle based on “ecoflex-coupling method”. The three dimensional (3D) human skeletal muscle myobundles was fabricated in series with ecoflex (platinum-catalyzed silicones) film containing microbeads. Through mapping the displacement of the microbeads in ecoflex, a linear relation between muscle contractile force production and ecoflex film stretch was established. Then the force production of engineered muscle was real-time monitored in situ.