Biofabrication of tissue engineering vascular systems.

TitleBiofabrication of tissue engineering vascular systems.
Publication TypeJournal Article
Year of Publication2021
AuthorsQ Zhang, È Bosch-Rué, RA Pérez, and GA Truskey
JournalAPL bioengineering
Start Page021507
Date Published06/2021

Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as <i>in vitro</i> model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on <i>in vitro</i> applications. <i>In vitro</i> applications of TEVS for disease modeling are discussed.

Short TitleAPL bioengineering