Advancing cardiovascular tissue engineering.

TitleAdvancing cardiovascular tissue engineering.
Publication TypeJournal Article
Year of Publication2016
AuthorsGA Truskey
Start PageF1000 Faculty Rev-1045
Date Published01/2016

Cardiovascular tissue engineering offers the promise of biologically based repair of injured and damaged blood vessels, valves, and cardiac tissue. Major advances in cardiovascular tissue engineering over the past few years involve improved methods to promote the establishment and differentiation of induced pluripotent stem cells (iPSCs), scaffolds from decellularized tissue that may produce more highly differentiated tissues and advance clinical translation, improved methods to promote vascularization, and novel in vitro microphysiological systems to model normal and diseased tissue function. iPSC technology holds great promise, but robust methods are needed to further promote differentiation. Differentiation can be further enhanced with chemical, electrical, or mechanical stimuli.

Short TitleF1000research