The liver is a vital organ that serves as the central location for pharmaceutical drug metabolism. It is also susceptible to chemicals and foreign substances that can impair this critical function. Therefore, it is imperative to accurately replicate this system when screening drug candidates for pharmaceutical development. Our lab is currently working towards engineering a microphysiological system that can sustain human hepatocyte (liver cell) function outside the body that mimics what is naturally seen in the body. Ultimately, this liver system will be integrated with our musculoskeletal and blood vessels systems to investigate various drug interactions outside the body.